To bring about The End of Days, The Fifth must come into being. Each Horseman has his or her part to play subject to the constraints they are given and the whims of their own personality. While traversing time and space, each does so. Pestilence spreads not just a virus to infect the body but a far more sinister one that infects the spirit, while War beats the drums that will bring the tribes of man to each other’s throats. Famine delivers scarcity from abundance, and Death, well, Death does what he has always done - he ferries the souls to their determined destination.
All of this is done to give birth to The Fifth.